U.S. SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549

                                    FORM 3

            INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
        Section 17(a) of the Public Utility Holding Company Act of 1935
            or Section 30(f) of the Investment Company Act of 1940

1. Name and Address of Reporting Person*

   Mancuso   Frank    G.

   (Last)    (First)  (Middle)


   c/o Delcath Systems, Inc., 1100 Summer St.

   (Street)


   Stamford   CT      06905

   (City)   (State)  (Zip)


2. Date of Event Requiring Statement (Month/Day/Year)

   10/19/00


3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary)



4. Issuer Name and Ticker or Trading Symbol

   Delcath Systems, Inc. and "DCTH" (1) and "DCT" (2)


5. Relationship of Reporting Person to Issuer (Check all applicable)

   /X/ Director                            / / 10% Owner
   / / Officer (give title below)          / / Other (specify below)


6. If Amendment, Date of Original (Month/Day/Year)



7. Individual or Joint/Group Reporting (Check applicable line)

   /X/ Form filed by One Reporting Person
   / / Form filed by More than One Reporting Person


* If the Form is filed by more than one Reporting Person, see instruction
  5(b)(v).

































Table I -- Non-Derivative Securities Beneficially Owned 2. Amount 3. Ownership of Secu- Form: rities Direct 4. Nature of Bene- (D) or Indirect ficially Indirect Beneficial Owned (I) Ownership 1. Title of Security (Instr. 4) (Instr. 5) (Instr. 5) - -------------------------------- ------------- ------------- ---------------- Common Stock, par value $.01 per share 38,978 D Common Stock, par value $.01 per share 14,469 I Beneficial remainder interest in Venkol Trust
Table II--Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities) 2. Date Exercisable and Expiration Date 3. Title and Amount of Securities Underlying Derivative (Month/Day/Year) Security (Instr. 4) ---------------------- ----------------------------------------------------------- Date Amount or 1. Title of Derivative Exercis- Expiration Title Number of Security (Instr. 4) able Date Shares - ---------------------------------------------- ---------- ---------- ---------------------------------------------- ----------- Options (3) 01/04 Common stock, par value $.01 per share 34,504 Options (3) 12/04 Common stock, par value $.01 per share 11,214 Options 12/07/00 12/04 Common stock, par value $.01 per share 11,214 Warrants (4) 1/16/01 Common stock, par value $.01 per share 920 Warrants (4) 4/30/02 Common stock, par value $.01 per share 504 Warrants (4) 1/16/01 Common stock, par value $.01 per share 28 5. Ownership Form of Derivative 4. Conver- Security: sion or Direct 6. Nature of Exercise (D) or Indirect Price of Indirect Beneficial 1. Title of Derivative Derivative (I) Ownership Security (Instr. 4) Security (Instr. 5) (Instr. 5) - ---------------------------------------------- ------------- ------------- -------------- Options $4.93 D Options $2.90 D Options $2.90 D Warrants $10.87 D Warrants $14.87 D Warrants $10.87 I By Venkol Trust (5)
Explanation of Responses: (1) Nadaq symbol. (2) Boston Stock Exchange symbol. (3) These options have vested and are presently exercisable. (4) These warrants are presently exercisable. (5) The reporting person has a beneficial remainder interest in warrrants held by the Venkol Trust. /s/ Frank G. Mancuso 10/19/00 - --------------------------------------- -------------------------- **Signature of Reporting Person Date ** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).